Neural tube defects in Newfoundland.

Neural tube defects in Newfoundland.

Neural tube defects in Newfoundland SIR-It was recently suggested in this journal that the 1988-89 peak in the birth prevalence of neural tube defects (NTD) in eastern Turkey was due to the Chernobyl disaster.' Two other reports from the western hemisphere have described dramatic increases in the birth prevalence of NTD. In Jamaica the increase in several types of NTD between July 1989 and Marc...

Bayesian small area cluster analysis of neural tube defects in Newfoundland.

BACKGROUND The incidence of neural tube defects (NTDs) is declining worldwide due to the implementation of folic acid supplementation programs. Such a program was implemented over 1996-97 in Newfoundland and Labrador, Canada. The geographical distribution of birth incidence was studied prior to and after the implementation of the program to identify regions of residual high incidence. Excess re...

Neural tube defects

lower limbs and other major organ malformations.4 Complex dysraphic states due to aberrant integration of the notochord include split cord malformation (SCM) or diastematomyelia: a congenital spinal anomaly in which there is longitudinal splitting of the spinal cord.5,6 Causes of NTDs are multifactorial and defects in several different genes can underlie the genetic basis of this disease.1 Howe...

Neural-tube defects.

Neural tube defects.

The purpose of this article is to describe the etiology of neural tube defects (NTDs) and the role of folic acid in their prevention. NTDs are all too common and devastating outcomes of many pregnancies. The brain and spinal cord malformations that develop during gestation in the NTD-affected pregnancies are expressed through various anomalies. Estimates by the Centers for Disease Control and P...